Structural basis of anti-SARS-CoV-2 activity of HCQ: specific binding to N protein to disrupt its interaction with nucleic acids and LLPS

SARS-CoV-2 nucleocapsid (N) protein plays the essential roles in key steps of the viral life cycle, thus representing a top drug target. Functionality of N protein including liquid–liquid phase separation (LLPS) depends on its interaction with nucleic acids. Only the variants with N proteins functio...

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Detalles Bibliográficos
Autores principales: Dang, Mei, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392676/
https://www.ncbi.nlm.nih.gov/pubmed/37529681
http://dx.doi.org/10.1017/qrd.2021.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392676/
https://www.ncbi.nlm.nih.gov/pubmed/37529681
http://dx.doi.org/10.1017/qrd.2021.12

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