Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability

Human mutations in the gene encoding the solute carrier (SLC) 6A17 caused intellectual disability (ID). The physiological role of SLC6A17 and pathogenesis of SLC6A17-based-ID were both unclear. Here, we report learning deficits in Slc6a17 knockout and point mutant mice. Biochemistry, proteomic, and...

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Detalles Bibliográficos
Autores principales: Jia, Xiaobo, Zhu, Jiemin, Bian, Xiling, Liu, Sulin, Yu, Sihan, Liang, Wenjun, Jiang, Lifen, Mao, Renbo, Zhang, Wenxia, Rao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393021/
https://www.ncbi.nlm.nih.gov/pubmed/37440432
http://dx.doi.org/10.7554/eLife.86972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393021/
https://www.ncbi.nlm.nih.gov/pubmed/37440432
http://dx.doi.org/10.7554/eLife.86972

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