FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Abnormal expansions of GGGGCC repeat sequence in the noncoding region of the C9orf72 gene is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). The expanded repeat sequence is translated into dipeptide repeat proteins (DPRs) by noncanonical repe...

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Detalles Bibliográficos
Autores principales: Fujino, Yuzo, Ueyama, Morio, Ishiguro, Taro, Ozawa, Daisaku, Ito, Hayato, Sugiki, Toshihiko, Murata, Asako, Ishiguro, Akira, Gendron, Tania, Mori, Kohji, Tokuda, Eiichi, Taminato, Tomoya, Konno, Takuya, Koyama, Akihide, Kawabe, Yuya, Takeuchi, Toshihide, Furukawa, Yoshiaki, Fujiwara, Toshimichi, Ikeda, Manabu, Mizuno, Toshiki, Mochizuki, Hideki, Mizusawa, Hidehiro, Wada, Keiji, Ishikawa, Kinya, Onodera, Osamu, Nakatani, Kazuhiko, Petrucelli, Leonard, Taguchi, Hideki, Nagai, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393046/
https://www.ncbi.nlm.nih.gov/pubmed/37461319
http://dx.doi.org/10.7554/eLife.84338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393046/
https://www.ncbi.nlm.nih.gov/pubmed/37461319
http://dx.doi.org/10.7554/eLife.84338

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