Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength

The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell contacts through adherens and tight junctions. To investigate the signaling that regulates vascular barrier...

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Detalles Bibliográficos
Autores principales: Mahlandt, Eike K, Palacios Martínez, Sebastián, Arts, Janine JG, Tol, Simon, van Buul, Jaap D, Goedhart, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393062/
https://www.ncbi.nlm.nih.gov/pubmed/37449837
http://dx.doi.org/10.7554/eLife.84364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393062/
https://www.ncbi.nlm.nih.gov/pubmed/37449837
http://dx.doi.org/10.7554/eLife.84364

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