Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia

BACKGROUND: Surgical site infections (SSIs), especially when caused by multidrug-resistant (MDR) bacteria, are a major healthcare concern worldwide. For optimal treatment and prevention of antimicrobial resistance, it is important for clinicians to be aware of local drug-resistant bacterial pathogen...

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Autores principales: Al-Said, Hamdi M., Alghamdi, Ahmed, Ashgar, Sami S., Jalal, Naif A., Faidah, Hani S., Johargy, Ayman K., Momenah, Aiman M., Barhameen, Abeer A., Hariri, Sumyya H., Bantun, Farkad, Althobiany, Essa, Khidir, Elshiekh B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393095/
https://www.ncbi.nlm.nih.gov/pubmed/37533663
http://dx.doi.org/10.4103/sjmms.sjmms_405_22
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author Al-Said, Hamdi M.
Alghamdi, Ahmed
Ashgar, Sami S.
Jalal, Naif A.
Faidah, Hani S.
Johargy, Ayman K.
Momenah, Aiman M.
Barhameen, Abeer A.
Hariri, Sumyya H.
Bantun, Farkad
Althobiany, Essa
Khidir, Elshiekh B.
author_facet Al-Said, Hamdi M.
Alghamdi, Ahmed
Ashgar, Sami S.
Jalal, Naif A.
Faidah, Hani S.
Johargy, Ayman K.
Momenah, Aiman M.
Barhameen, Abeer A.
Hariri, Sumyya H.
Bantun, Farkad
Althobiany, Essa
Khidir, Elshiekh B.
author_sort Al-Said, Hamdi M.
collection PubMed
description BACKGROUND: Surgical site infections (SSIs), especially when caused by multidrug-resistant (MDR) bacteria, are a major healthcare concern worldwide. For optimal treatment and prevention of antimicrobial resistance, it is important for clinicians to be aware of local drug-resistant bacterial pathogens that cause SSIs. OBJECTIVE: To determine the frequency patterns of drug-resistant bacterial strains causing SSIs at a tertiary care hospital in Saudi Arabia. METHODS: This retrospective study was conducted at the Microbiology laboratory of Al-Noor Specialist Hospital, Makkah, Saudi Arabia, and included wound swab samples from all cases of SSI between January 01, 2017, and December 31, 2021. The swabs were processed for the identification of bacterial strains and their resistance pattern to antibiotics according to the Clinical and Laboratory Standards Institute. RESULTS: A total of 5409 wound swabs were analyzed, of which 3604 samples (66.6%) were from male. Most samples were from the Department of Surgery (43.3%). A total of 14 bacterial strains were isolated, of which 9 were Gram-negative bacteria. The most common isolates were Klebsiella pneumoniae, followed by Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and vancomycin-resistant S. aureus (VRSA). In terms of MDR in 2021, the highest rate of carbapenem-resistance was in A. baumannii (97%). MDR was as follows: A. baumannii, 97%; K. pneumoniae, 81%; E. coli, 71%; MRSA, 60%; P. aeruginosa, 33%; VRE, 22%; and VRSA, 2%. CONCLUSION: This study showed that in the city of Makkah, Saudi Arabia, the rates of MDR bacteria are high, with the majority being Gram-negative.
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spelling pubmed-103930952023-08-02 Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia Al-Said, Hamdi M. Alghamdi, Ahmed Ashgar, Sami S. Jalal, Naif A. Faidah, Hani S. Johargy, Ayman K. Momenah, Aiman M. Barhameen, Abeer A. Hariri, Sumyya H. Bantun, Farkad Althobiany, Essa Khidir, Elshiekh B. Saudi J Med Med Sci Original Article BACKGROUND: Surgical site infections (SSIs), especially when caused by multidrug-resistant (MDR) bacteria, are a major healthcare concern worldwide. For optimal treatment and prevention of antimicrobial resistance, it is important for clinicians to be aware of local drug-resistant bacterial pathogens that cause SSIs. OBJECTIVE: To determine the frequency patterns of drug-resistant bacterial strains causing SSIs at a tertiary care hospital in Saudi Arabia. METHODS: This retrospective study was conducted at the Microbiology laboratory of Al-Noor Specialist Hospital, Makkah, Saudi Arabia, and included wound swab samples from all cases of SSI between January 01, 2017, and December 31, 2021. The swabs were processed for the identification of bacterial strains and their resistance pattern to antibiotics according to the Clinical and Laboratory Standards Institute. RESULTS: A total of 5409 wound swabs were analyzed, of which 3604 samples (66.6%) were from male. Most samples were from the Department of Surgery (43.3%). A total of 14 bacterial strains were isolated, of which 9 were Gram-negative bacteria. The most common isolates were Klebsiella pneumoniae, followed by Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and vancomycin-resistant S. aureus (VRSA). In terms of MDR in 2021, the highest rate of carbapenem-resistance was in A. baumannii (97%). MDR was as follows: A. baumannii, 97%; K. pneumoniae, 81%; E. coli, 71%; MRSA, 60%; P. aeruginosa, 33%; VRE, 22%; and VRSA, 2%. CONCLUSION: This study showed that in the city of Makkah, Saudi Arabia, the rates of MDR bacteria are high, with the majority being Gram-negative. Wolters Kluwer - Medknow 2023 2023-07-15 /pmc/articles/PMC10393095/ /pubmed/37533663 http://dx.doi.org/10.4103/sjmms.sjmms_405_22 Text en Copyright: © 2023 Saudi Journal of Medicine & Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Al-Said, Hamdi M.
Alghamdi, Ahmed
Ashgar, Sami S.
Jalal, Naif A.
Faidah, Hani S.
Johargy, Ayman K.
Momenah, Aiman M.
Barhameen, Abeer A.
Hariri, Sumyya H.
Bantun, Farkad
Althobiany, Essa
Khidir, Elshiekh B.
Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title_full Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title_fullStr Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title_full_unstemmed Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title_short Isolation and Detection of Drug-Resistant Bacterial Pathogens in Postoperative Wound Infections at a Tertiary Care Hospital in Saudi Arabia
title_sort isolation and detection of drug-resistant bacterial pathogens in postoperative wound infections at a tertiary care hospital in saudi arabia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393095/
https://www.ncbi.nlm.nih.gov/pubmed/37533663
http://dx.doi.org/10.4103/sjmms.sjmms_405_22
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