Cargando…

Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment

While blood gene signatures have shown promise in tuberculosis (TB) diagnosis and treatment monitoring, most signatures derived from a single cohort may be insufficient to capture TB heterogeneity in populations and individuals. Here we report a new generalized approach combining a network-based met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vargas, Roger, Abbott, Liam, Bower, Daniel, Frahm, Nicole, Shaffer, Mike, Yu, Wen-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393163/ https://www.ncbi.nlm.nih.gov/pubmed/37471455 http://dx.doi.org/10.1371/journal.pcbi.1010770

Ejemplares similares

A hypoxia- and lactate metabolism-related gene signature to predict prognosis of sepsis: discovery and validation in independent cohorts
por: Peng, Yaojun, et al.
Publicado: (2023)

Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker
por: Izquierdo-Garcia, José Luis, et al.
Publicado: (2020)

Comprehensive DNA Signature Discovery and Validation
por: Phillippy, Adam M, et al.
Publicado: (2007)

Discovery and Validation of an Epithelial-Mesenchymal Transition-Based Signature in Gastric Cancer by Genomics and Prognosis Analysis
por: Xu, Huiyong, et al.
Publicado: (2021)

Hit Generation in TB Drug Discovery: From Genome to Granuloma
por: Yuan, Tianao, et al.
Publicado: (2018)

The diversity of latent TB
por: Young, Douglas
Publicado: (2010)

Correction to Hit Generation in TB Drug Discovery: From Genome to Granuloma
por: Yuan, Tianao, et al.
Publicado: (2019)

The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery
por: Yuan, Tianao, et al.
Publicado: (2021)

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
por: Penn-Nicholson, Adam, et al.
Publicado: (2019)

Discovery and Validation of Urinary Molecular Signature of Early Sepsis
por: Bandyopadhyay, Sabyasachi, et al.
Publicado: (2020)

Treatment and care of TB across Europe
por: Kirk, Ole
Publicado: (2014)

Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease
por: Mutavhatsindi, Hygon, et al.
Publicado: (2021)

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
por: Penn-Nicholson, Adam, et al.
Publicado: (2019)

Genome-wide discovery and validation of Eucalyptus small RNAs reveals variable patterns of conservation and diversity across species of Myrtaceae
por: Pappas, Marília de Castro Rodrigues, et al.
Publicado: (2015)

Development and Validation of a 7-Gene Inflammatory Signature Forecasts Prognosis and Diverse Immune Landscape in Lung Adenocarcinoma
por: Nai, Aitao, et al.
Publicado: (2022)

The ATLAS discovery potential for a heavy charged Higgs boson in $gg \to tbH^{+-}$ with $H^{+-} \to tb$
por: Assamagan, Ketevi A, et al.
Publicado: (2004)

The ATLAS discovery potential for a heavy charged Higgs boson in gg->tbH^{+-} with H^{+-}->tb
por: Assamagan, Ketevi A, et al.
Publicado: (2004)

Genetic discovery and risk characterization in type 2 diabetes across diverse populations
por: Polfus, Linda M., et al.
Publicado: (2021)

Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
por: Limothai, Umaporn, et al.
Publicado: (2022)

Identification and Validation of HCC-specific Gene Transcriptional Signature for Tumor Antigen Discovery
por: Petrizzo, Annacarmen, et al.
Publicado: (2016)

Discovery and Features of an Alkylating Signature in Colorectal Cancer
por: Gurjao, Carino, et al.
Publicado: (2021)

Lung Inflammation Signature in Post-COVID-19 TB Patients
por: Shepelkova, Galina S., et al.
Publicado: (2023)

Construction and Validation of a 13-Gene Signature for Prognosis Prediction in Medulloblastoma
por: Li, Chang, et al.
Publicado: (2020)

Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma
por: Yang, Jinpo, et al.
Publicado: (2022)

Novel pyroptosis-associated genes signature for predicting the prognosis of sarcoma and validation
por: Wen, Hao, et al.
Publicado: (2022)

Development and validation of an immune‐related gene signature for prognosis in Lung adenocarcinoma
por: Guo, Zehuai, et al.
Publicado: (2023)

Identification and validation of GABA‐driven subtypes and prognosis signature of lung adenocarcinoma
por: Li, Lifeng, et al.
Publicado: (2023)

Discovery and Validation of Novel Expression Signature for Postcystectomy Recurrence in High-Risk Bladder Cancer
por: Mitra, Anirban P., et al.
Publicado: (2014)

Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort
por: Lawton, Michael, et al.
Publicado: (2019)

A blood RNA transcript signature for TB exposure in household contacts
por: Kwan, Philip Kam Weng, et al.
Publicado: (2020)

On reliable discovery of molecular signatures
por: Nilsson, Roland, et al.
Publicado: (2009)

Mapping TB resistance
por: LeBrasseur, Nicole
Publicado: (2009)

Genetics of validated Parkinson’s disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts
por: Lawton, Michael, et al.
Publicado: (2022)

Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types
por: Chen, Tenghui, et al.
Publicado: (2016)

Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour
por: Rey, Sonia, et al.
Publicado: (2021)

Development and Validation of a Seven-Gene Signature for Predicting the Prognosis of Lung Adenocarcinoma
por: Zhang, Yingqing, et al.
Publicado: (2020)

Development and Validation of an Autophagy-Related Gene Signature for Predicting the Prognosis of Hepatocellular Carcinoma
por: Zhang, Jianlin, et al.
Publicado: (2021)

Development and Validation of a Pyroptosis-Related Signature for Predicting Prognosis in Hepatocellular Carcinoma
por: Ding, Jianfeng, et al.
Publicado: (2022)

Identification and Validation of Inflammatory Response-Related Gene Signatures to Predict the Prognosis of Neuroblastoma
por: Song, Jiye, et al.
Publicado: (2022)

Identification and validation of prognosis-associated DNA repair gene signatures in colorectal cancer
por: Song, Dingli, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_alu24v5e8rp86tsorav8edvr5c