Sirolimus-eluting airway stent reduces profibrotic Th17 cells and inhibits laryngotracheal stenosis

Laryngotracheal stenosis (LTS) is pathologic fibrotic narrowing of the larynx and trachea characterized by hypermetabolic fibroblasts and CD4(+) T cell–mediated inflammation. However, the role of CD4(+) T cells in promoting LTS fibrosis is unknown. The mTOR signaling pathways have been shown to regu...

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Detalles Bibliográficos
Autores principales: Motz, Kevin M., Lina, Ioan A., Samad, Idris, Murphy, Michael K., Duvvuri, Madhavi, Davis, Ruth J., Gelbard, Alexander, Chung, Liam, Chan-Li, Yee, Collins, Samuel, Powell, Jonathan D., Elisseeff, Jennifer H., Horton, Maureen R., Hillel, Alexander T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393235/
https://www.ncbi.nlm.nih.gov/pubmed/37159282
http://dx.doi.org/10.1172/jci.insight.158456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393235/
https://www.ncbi.nlm.nih.gov/pubmed/37159282
http://dx.doi.org/10.1172/jci.insight.158456

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