A covalent inhibitor of K-Ras(G12C) induces MHC-I presentation of haptenated peptide neoepitopes targetable by immunotherapy

Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy. Immunotherapies directed at MHC-I complexes have expanded the scope of antigens and enabled the direct targeting of intracellular oncoproteins at the cell surface. We asked whether covalent drugs that alkylate mutated res...

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Detalles Bibliográficos
Autores principales: Zhang, Ziyang, Rohweder, Peter J., Ongpipattanakul, Chayanid, Basu, Koli, Bohn, Markus F., Dugan, Eli J., Steri, Veronica, Hann, Byron, Shokat, Kevan M., Craik, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393267/
https://www.ncbi.nlm.nih.gov/pubmed/36099883
http://dx.doi.org/10.1016/j.ccell.2022.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393267/
https://www.ncbi.nlm.nih.gov/pubmed/36099883
http://dx.doi.org/10.1016/j.ccell.2022.07.005

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