Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an expansive proteostatic network. We have discovered...

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Detalles Bibliográficos
Autores principales: Lazaro-Pena, Maria I, Cornwell, Adam B, Diaz-Balzac, Carlos A, Das, Ritika, Ward, Zachary C, Macoretta, Nicholas, Thakar, Juilee, Samuelson, Andrew V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393298/
https://www.ncbi.nlm.nih.gov/pubmed/37338980
http://dx.doi.org/10.7554/eLife.85792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393298/
https://www.ncbi.nlm.nih.gov/pubmed/37338980
http://dx.doi.org/10.7554/eLife.85792

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