Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity

In acute lung injury, the lung endothelial barrier is compromised. Loss of endothelial barrier integrity occurs in association with decreased levels of the tight junction protein claudin-5. Restoration of their levels by gene transfection may improve the vascular barrier, but how to limit transfecti...

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Detalles Bibliográficos
Autores principales: Sanwal, Rajiv, Mintsopoulos, Victoria, Ditmans, Mihails, Lang, Alice, Latreille, Elyse, Ghaffari, Siavash, Khosraviani, Negar, Karshafian, Raffi, Leong-Poi, Howard, Hwang, David M., Brochard, Laurent, Goffi, Alberto, Slutsky, Arthur S., Lee, Warren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393345/
https://www.ncbi.nlm.nih.gov/pubmed/37310768
http://dx.doi.org/10.1152/ajplung.00107.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393345/
https://www.ncbi.nlm.nih.gov/pubmed/37310768
http://dx.doi.org/10.1152/ajplung.00107.2023

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