mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of protein synthesis that senses and responds to a variety of stimuli to coordinate cellular metabolism with environmental conditions. To ensure that protein synthesis is inhibited during unfavorable conditions, translatio...

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Detalles Bibliográficos
Autores principales: Hofmann, Christoph, Löwenthal, Zoe, Aghajani, Marjan, Kaufman, Randal J., Katus, Hugo A., Frey, Norbert, Glembotski, Christopher C., Völkers, Mirko, Doroudgar, Shirin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393365/
https://www.ncbi.nlm.nih.gov/pubmed/37294892
http://dx.doi.org/10.1152/ajpheart.00682.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393365/
https://www.ncbi.nlm.nih.gov/pubmed/37294892
http://dx.doi.org/10.1152/ajpheart.00682.2022

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