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N-terminal intrinsic disorder is an ancestral feature of Gγ subunits that influences the balance between different Gβγ signaling axes in yeast

Activated G protein-coupled receptors promote the dissociation of heterotrimeric G proteins into Gα and Gβγ subunits that bind to effector proteins to drive intracellular signaling responses. In yeast, Gβγ subunits coordinate the simultaneous activation of multiple signaling axes in response to mati...

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Detalles Bibliográficos
Autores principales: Su, Xinya, Pang, Yui Tik, Li, Wei, Gumbart, J.C., Kelley, Joshua, Torres, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393545/
https://www.ncbi.nlm.nih.gov/pubmed/37354971
http://dx.doi.org/10.1016/j.jbc.2023.104947