Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

BACKGROUND: In Huntington's disease (HD), a CAG repeat expansion mutation in the Huntingtin (HTT) gene drives a gain-of-function toxicity that disrupts mRNA processing. Although dysregulation of gene splicing has been shown in human HD post-mortem brain tissue, post-mortem analyses are likely c...

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Detalles Bibliográficos
Autores principales: Tano, Vincent, Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Bégin, Jocelyn, Tan, Willy Wei Li, Pouladi, Mahmoud A., Langley, Sarah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393612/
https://www.ncbi.nlm.nih.gov/pubmed/37481821
http://dx.doi.org/10.1016/j.ebiom.2023.104720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393612/
https://www.ncbi.nlm.nih.gov/pubmed/37481821
http://dx.doi.org/10.1016/j.ebiom.2023.104720

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