The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD mice

BACKGROUND: Previously, we showed that the sphingosine-1-phosphate (S1P) transporter spinster 2 (Spns2) mediates activation of microglia in response to amyloid β peptide (Aβ). Here, we investigated if Ponesimod, a functional S1P receptor 1 (S1PR1) antagonist, prevents Aβ-induced activation of glial...

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Detalles Bibliográficos
Autores principales: Zhu, Zhihui, Zhang, Liping, Elsherbini, Ahmed, Crivelli, Simone M., Tripathi, Priyanka, Harper, Carmen, Quadri, Zainuddin, Spassieva, Stefka D., Bieberich, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393615/
https://www.ncbi.nlm.nih.gov/pubmed/37480622
http://dx.doi.org/10.1016/j.ebiom.2023.104713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393615/
https://www.ncbi.nlm.nih.gov/pubmed/37480622
http://dx.doi.org/10.1016/j.ebiom.2023.104713

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