Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

Iroquois transcription factor gene IRX3 is highly expressed in 20–30% of acute myeloid leukemia (AML) and contributes to the pathognomonic differentiation block. Intron 8 FTO sequences ∼220kB downstream of IRX3 exhibit histone acetylation, DNA methylation, and contacts with the IRX3 promoter, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393733/
https://www.ncbi.nlm.nih.gov/pubmed/37539037
http://dx.doi.org/10.1016/j.isci.2023.107319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393733/
https://www.ncbi.nlm.nih.gov/pubmed/37539037
http://dx.doi.org/10.1016/j.isci.2023.107319

Ejemplares similares