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Group size planning for breedings of gene-modified mice and other organisms following Mendelian inheritance
Colony management of gene-modified animals is time-consuming, costly and affected by random events related to Mendelian genetics, fertility and litter size. Careful planning is mandatory to ensure successful outcomes using the least number of animals, hence adhering to the 3R principles of animal we...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393774/ https://www.ncbi.nlm.nih.gov/pubmed/37488410 http://dx.doi.org/10.1038/s41684-023-01213-1 |