Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic poly(A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73, is the first known CPA inhibitor (CPAi) in mammalian cells. Here we show that JTE-607 perturbs gene expression through both tr...

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Detalles Bibliográficos
Autores principales: Cui, Yange, Wang, Luyang, Ding, Qingbao, Shin, Jihae, Cassel, Joel, Liu, Qin, Salvino, Joseph M., Tian, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394034/
https://www.ncbi.nlm.nih.gov/pubmed/37528120
http://dx.doi.org/10.1038/s41467-023-39793-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394034/
https://www.ncbi.nlm.nih.gov/pubmed/37528120
http://dx.doi.org/10.1038/s41467-023-39793-8

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