Cargando…

Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic poly(A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73, is the first known CPA inhibitor (CPAi) in mammalian cells. Here we show that JTE-607 perturbs gene expression through both tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Yange, Wang, Luyang, Ding, Qingbao, Shin, Jihae, Cassel, Joel, Liu, Qin, Salvino, Joseph M., Tian, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394034/ https://www.ncbi.nlm.nih.gov/pubmed/37528120 http://dx.doi.org/10.1038/s41467-023-39793-8

Ejemplares similares

CRISPRpas: programmable regulation of alternative polyadenylation by dCas9
por: Shin, Jihae, et al.
Publicado: (2021)

SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3′ end processing
por: Yu, Simei, et al.
Publicado: (2018)

Exploring the Impact of Cleavage and Polyadenylation Factors on Pre-mRNA Splicing Across Eukaryotes
por: Lepennetier, Gildas, et al.
Publicado: (2017)

Electrostatic Interactions between CSTF2 and pre-mRNA Drive Cleavage and Polyadenylation
por: Masoumzadeh, Elahe, et al.
Publicado: (2022)

Cleavage and polyadenylation: Ending the message expands gene regulation
por: Neve, Jonathan, et al.
Publicado: (2017)

Transcriptome sequencing suggests that pre-mRNA splicing counteracts widespread intronic cleavage and polyadenylation
por: Vlasenok, Maria, et al.
Publicado: (2023)

Regulation of Intronic Polyadenylation by PCF11 Impacts mRNA Expression of Long Genes
por: Wang, Ruijia, et al.
Publicado: (2019)

Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex
por: Hill, Chris H., et al.
Publicado: (2019)

Transcriptional activity regulates alternative cleavage and polyadenylation
por: Ji, Zhe, et al.
Publicado: (2011)

Hydroxyurea and inactivation of checkpoint kinase MEC1 inhibit transcription termination and pre-mRNA cleavage at polyadenylation sites in budding yeast
por: Kaur, Pritpal, et al.
Publicado: (2023)

Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders
por: Nourse, Jamie, et al.
Publicado: (2020)

Post‐transcriptional polyadenylation site cleavage maintains 3′‐end processing upon DNA damage
por: Sfaxi, Rym, et al.
Publicado: (2023)

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
por: Ren, Xueying, et al.
Publicado: (2021)

Sequential Polyadenylation to Enable Alternative mRNA 3’ End Formation
por: Hao, Yajing, et al.
Publicado: (2023)

A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation
por: Gruber, Andreas J., et al.
Publicado: (2016)

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
por: Kaida, Daisuke, et al.
Publicado: (2010)

A compensatory link between cleavage/polyadenylation and mRNA turnover regulates steady-state mRNA levels in yeast
por: Moqtaderi, Zarmik, et al.
Publicado: (2022)

A compendium of conserved cleavage and polyadenylation events in mammalian genes
por: Wang, Ruijia, et al.
Publicado: (2018)

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma
por: Chen, Shi-lu, et al.
Publicado: (2021)

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
por: Shi, Yongsheng, et al.
Publicado: (2015)

Characterization of mRNA polyadenylation in the apicomplexa
por: Stevens, Ashley T., et al.
Publicado: (2018)

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development
por: Lin, Andrew C, et al.
Publicado: (2009)

Characterization of the Distal Polyadenylation Site of the ß-Adducin (Add2) Pre-mRNA
por: Costessi, Luisa, et al.
Publicado: (2013)

Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs
por: Guvenek, Aysegul, et al.
Publicado: (2022)

Analysis of alterative cleavage and polyadenylation by 3′ region extraction and deep sequencing
por: Hoque, Mainul, et al.
Publicado: (2012)

Direct Sequencing of Arabidopsis thaliana RNA Reveals Patterns of Cleavage and Polyadenylation
por: Sherstnev, Alexander, et al.
Publicado: (2012)

hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
por: Fischl, Harry, et al.
Publicado: (2019)

Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism
por: Shin, Jihae, et al.
Publicado: (2017)

Genome level analysis of rice mRNA 3′-end processing signals and alternative polyadenylation
por: Shen, Yingjia, et al.
Publicado: (2008)

Molecular Insights into mRNA Polyadenylation and Deadenylation
por: Liu, Junjie, et al.
Publicado: (2022)

Identification and targeting of selective vulnerability rendered by tamoxifen resistance
por: Singh, Madhurendra, et al.
Publicado: (2020)

Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA
por: Ikeda, Takayuki, et al.
Publicado: (2020)

Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control
por: Li, Wencheng, et al.
Publicado: (2016)

PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
por: Yang, Yan, et al.
Publicado: (2016)

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential
por: Malka, Yuval, et al.
Publicado: (2022)

Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
por: Zheng, Dinghai, et al.
Publicado: (2018)

Periostin renders cardiomyocytes vulnerable to acute myocardial infarction via pro‐apoptosis
por: Hu, Yanlei, et al.
Publicado: (2022)

Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy
por: Marsollier, Anne-Charlotte, et al.
Publicado: (2018)

The C. elegans 3′ UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3′-UTR biology, and miRNA targeting
por: Steber, Hannah S., et al.
Publicado: (2019)

Alternative polyadenylation of mRNA and its role in cancer
por: Yuan, Fuwen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3f1bigm6p87ilm9vurbpmfh8qb