DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost

Type II topoisomerase (Top2) poisoning therapy is used to treat a broad range of cancers via induction of double strand breaks (DSBs) in cells undergoing replication and transcription. Preventing the repair of DSBs via inhibition of DNA-PK, an inhibitor of non-homologous end-joining (NHEJ), increase...

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Detalles Bibliográficos
Autores principales: Wang, Taixiang, Kyle, Alastair H., Baker, Jennifer H. E., Liu, Nannan A., Banáth, Judit P., Minchinton, Andrew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394067/
https://www.ncbi.nlm.nih.gov/pubmed/37528151
http://dx.doi.org/10.1038/s41598-023-39649-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394067/
https://www.ncbi.nlm.nih.gov/pubmed/37528151
http://dx.doi.org/10.1038/s41598-023-39649-7

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