Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

OBJECTIVE: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively. Most efficacious are so-called second-generation synthetic agonists such as AM5...

Descripción completa

Detalles Bibliográficos
Autores principales: Petersen, Jacob Emil, Pedersen, Maria Hauge, Dmytriyeva, Oksana, Nellemose, Emilie, Arora, Tulika, Engelstoft, Maja Storm, Asher, Wesley B., Javitch, Jonathan A., Schwartz, Thue W., Trauelsen, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394103/
https://www.ncbi.nlm.nih.gov/pubmed/37348738
http://dx.doi.org/10.1016/j.molmet.2023.101757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394103/
https://www.ncbi.nlm.nih.gov/pubmed/37348738
http://dx.doi.org/10.1016/j.molmet.2023.101757

Ejemplares similares