Cargando…

Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity

Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakayasu, Ernesto S., Bramer, Lisa M., Ansong, Charles, Schepmoes, Athena A., Fillmore, Thomas L., Gritsenko, Marina A., Clauss, Therese R., Gao, Yuqian, Piehowski, Paul D., Stanfill, Bryan A., Engel, Dave W., Orton, Daniel J., Moore, Ronald J., Qian, Wei-Jun, Sechi, Salvatore, Frohnert, Brigitte I., Toppari, Jorma, Ziegler, Anette-G., Lernmark, Åke, Hagopian, William, Akolkar, Beena, Smith, Richard D., Rewers, Marian J., Webb-Robertson, Bobbie-Jo M., Metz, Thomas O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394168/ https://www.ncbi.nlm.nih.gov/pubmed/37390828 http://dx.doi.org/10.1016/j.xcrm.2023.101093

Ejemplares similares

Extending Classification Algorithms to Case-Control Studies
por: Stanfill, Bryan, et al.
Publicado: (2019)

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes
por: Zhang, Qibin, et al.
Publicado: (2013)

Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers
por: Webb‐Robertson, Bobbie‐Jo M., et al.
Publicado: (2020)

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
por: Krischer, Jeffrey P., et al.
Publicado: (2023)

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study
por: Beyerlein, Andreas, et al.
Publicado: (2019)

Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
por: Elding Larsson, Helena, et al.
Publicado: (2016)

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
por: Li, Qian, et al.
Publicado: (2020)

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
por: Salami, Falastin, et al.
Publicado: (2022)

Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
por: Elding Larsson, Helena, et al.
Publicado: (2017)

Targeted proteomic assays for quantitation of proteins identified by proteogenomic analysis of ovarian cancer
por: Song, Ehwang, et al.
Publicado: (2017)

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
por: Bonifacio, Ezio, et al.
Publicado: (2018)

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
por: Auchtung, Thomas A., et al.
Publicado: (2022)

Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources
por: Frohnert, Brigitte I., et al.
Publicado: (2020)

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY
por: Lönnrot, Maria, et al.
Publicado: (2015)

Analgesic antipyretic use among young children in the TEDDY study: no association with islet autoimmunity
por: Lundgren, Markus, et al.
Publicado: (2017)

Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
por: Sharma, Ashok, et al.
Publicado: (2016)

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
por: Hippich, Markus, et al.
Publicado: (2019)

Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study
por: Törn, Carina, et al.
Publicado: (2015)

Early Infant Diet and Islet Autoimmunity in the TEDDY Study
por: Uusitalo, Ulla, et al.
Publicado: (2018)

Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
por: Törn, Carina, et al.
Publicado: (2016)

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
por: Vehik, Kendra, et al.
Publicado: (2019)

Metabolite-related dietary patterns and the development of islet autoimmunity
por: Johnson, Randi K., et al.
Publicado: (2019)

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
por: Vatanen, Tommi, et al.
Publicado: (2018)

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution
por: Piehowski, Paul D., et al.
Publicado: (2020)

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes
por: Kwon, Bum Chul, et al.
Publicado: (2022)

Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories
por: Kwon, Bum Chul, et al.
Publicado: (2022)

Prevalence of Obesity was Related to HLA-DQ in 2–4 Year Old Children at Genetic Risk for Type 1 Diabetes
por: Yang, Jimin, et al.
Publicado: (2014)

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses
por: Nakayasu, Ernesto S., et al.
Publicado: (2016)

Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
por: Mehta, Pooja, et al.
Publicado: (2023)

Validation of a Proteomic Signature of Lung Cancer Risk from Bronchial Specimens of Risk-Stratified Individuals
por: Rahman, S.M. Jamshedur, et al.
Publicado: (2023)

Effects of delayed NSAID administration after experimental eccentric contraction injury – A cellular and proteomics study
por: Bryant, Amy E., et al.
Publicado: (2017)

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
por: Törn, Carina, et al.
Publicado: (2022)

Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics
por: Sterner, Y, et al.
Publicado: (2011)

25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children: A Case–Control Study
por: Andrén Aronsson, Carin, et al.
Publicado: (2021)

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
por: Niinistö, Sari, et al.
Publicado: (2021)

Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response
por: Sarkar, Soumyadeep, et al.
Publicado: (2023)

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
por: Lindfors, Katri, et al.
Publicado: (2020)

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk
por: Uusitalo, Ulla, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uor57d47948aun1qeojv17mne7