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Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation
During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is sufficient to unleash the production of pro-inflammatory cytokines and neutroph...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394171/ https://www.ncbi.nlm.nih.gov/pubmed/37390829 http://dx.doi.org/10.1016/j.xcrm.2023.101098 |