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Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is sufficient to unleash the production of pro-inflammatory cytokines and neutroph...

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Detalles Bibliográficos
Autores principales:	Lentini, Germana, Famà, Agata, De Gaetano, Giuseppe Valerio, Coppolino, Francesco, Mahjoub, Ahlem Khachroub, Ryan, Liv, Lien, Egil, Espevik, Terje, Beninati, Concetta, Teti, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394171/ https://www.ncbi.nlm.nih.gov/pubmed/37390829 http://dx.doi.org/10.1016/j.xcrm.2023.101098

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