Cargando…

Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is sufficient to unleash the production of pro-inflammatory cytokines and neutroph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lentini, Germana, Famà, Agata, De Gaetano, Giuseppe Valerio, Coppolino, Francesco, Mahjoub, Ahlem Khachroub, Ryan, Liv, Lien, Egil, Espevik, Terje, Beninati, Concetta, Teti, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394171/ https://www.ncbi.nlm.nih.gov/pubmed/37390829 http://dx.doi.org/10.1016/j.xcrm.2023.101098

Ejemplares similares

Invasion and trafficking of hypervirulent group B streptococci in polarized enterocytes
por: De Gaetano, Giuseppe Valerio, et al.
Publicado: (2021)

In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract Infections
por: De Gaetano, Giuseppe Valerio, et al.
Publicado: (2023)

Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps
por: De Gaetano, Giuseppe Valerio, et al.
Publicado: (2023)

Streptococcus pneumoniae binds collagens and C1q via the SSURE repeats of the PfbB adhesin
por: De Gaetano, Giuseppe Valerio, et al.
Publicado: (2022)

Lysine Residues in the MK-Rich Region Are Not Required for Binding of the PbsP Protein From Group B Streptococci to Plasminogen
por: Coppolino, Francesco, et al.
Publicado: (2021)

Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci
por: Famà, Agata, et al.
Publicado: (2020)

The dual role of innate immunity during influenza
por: Biondo, Carmelo, et al.
Publicado: (2019)

CodY Is a Global Transcriptional Regulator Required for Virulence in Group B Streptococcus
por: Pellegrini, Angelica, et al.
Publicado: (2022)

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages
por: Ehrnström, Birgitta, et al.
Publicado: (2017)

Cellular Mechanisms of Oxidative Stress and Action in Melanoma
por: Venza, Mario, et al.
Publicado: (2015)

The plasminogen binding protein PbsP is required for brain invasion by hypervirulent CC17 Group B streptococci
por: Lentini, Germana, et al.
Publicado: (2018)

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection
por: Mohammadi, Nastaran, et al.
Publicado: (2016)

Essential Role of Interleukin-1 Signaling in Host Defenses Against Group B Streptococcus
por: Biondo, Carmelo, et al.
Publicado: (2014)

IL-10Rα expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma
por: Venza, Isabella, et al.
Publicado: (2015)

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
por: Skjesol, Astrid, et al.
Publicado: (2019)

RORα controls inflammatory state of human macrophages
por: Nejati Moharrami, Neda, et al.
Publicado: (2018)

ROS as Regulators of Cellular Processes in Melanoma
por: Venza, Isabella, et al.
Publicado: (2021)

Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci
por: Beninati, Concetta, et al.
Publicado: (2006)

The Relevance of IL-1-Signaling in the Protection against Gram-Positive Bacteria
por: Midiri, Angelina, et al.
Publicado: (2021)

MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection
por: Lei, Xuqiu, et al.
Publicado: (2023)

Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
por: Nilsen, Kaja Elisabeth, et al.
Publicado: (2023)

Yeast Killer Toxin-Like Candidacidal Ab6 Antibodies Elicited through the Manipulation of the Idiotypic Cascade
por: Polonelli, Luciano, et al.
Publicado: (2014)

Effective Caspase Inhibition Blocks Neutrophil Apoptosis and Reveals Mcl-1 as Both a Regulator and a Target of Neutrophil Caspase Activation
por: Wardle, David J., et al.
Publicado: (2011)

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant
por: Bottazzi, Barbara, et al.
Publicado: (2015)

Evolution of glomerular filtration rates and neutrophil gelatinase-associated lipocalin during treatment with direct acting antivirals
por: Strazzulla, Alessio, et al.
Publicado: (2018)

p38-MAPK Signals Survival by Phosphorylation of Caspase-8 and Caspase-3 in Human Neutrophils
por: Alvarado-Kristensson, Maria, et al.
Publicado: (2004)

Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism
por: Dubey, Megha, et al.
Publicado: (2016)

Polyvalent Bacterial Lysate Protects Against Pneumonia Independently of Neutrophils, IL-17A or Caspase-1 Activation
por: Ferrara, Florencia, et al.
Publicado: (2021)

Compartmentalization of TNF and IL-6 in meningitis and septic shock
por: Waage, Anders, et al.
Publicado: (1993)

Protective Activity of Streptococcus pneumoniae Spr1875 Protein Fragments Identified Using a Phage Displayed Genomic Library
por: Cardaci, Angela, et al.
Publicado: (2012)

Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever
por: Naess, Are, et al.
Publicado: (2016)

Immunogenic Properties of Streptococcus agalactiae FbsA Fragments
por: Papasergi, Salvatore, et al.
Publicado: (2013)

Rapid Profiling of the Antigen Regions Recognized by Serum Antibodies Using Massively Parallel Sequencing of Antigen-Specific Libraries
por: Domina, Maria, et al.
Publicado: (2014)

Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform
por: Domina, Maria, et al.
Publicado: (2016)

Effectiveness of Internet-Based Cognitive Behavioral Therapy With Telephone Support for Noncardiac Chest Pain: Randomized Controlled Trial
por: Thesen, Terje, et al.
Publicado: (2022)

Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) Predicts Renal Function Decline in Patients With Glomerular Diseases
por: Coppolino, Giuseppe, et al.
Publicado: (2020)

Caspase-8 mediates inflammation and disease in rodent malaria
por: Pereira, Larissa M. N., et al.
Publicado: (2020)

SLAMF1 is required for TLR4-mediated TRAM-TRIF–dependent signaling in human macrophages
por: Yurchenko, Maria, et al.
Publicado: (2018)

Bacterial secreted effectors and caspase-3 interactions
por: Wall, Daniel M, et al.
Publicado: (2014)

Biomarkers of cardio-renal damage in chronic kidney disease: one size cannot fit all
por: Bolignano, Davide, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8tvgslo97pd0p2urhgl4g29rdl