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Otoferlin as a multirole Ca(2+) signaling protein: from inner ear synapses to cancer pathways

Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca(2+)-binding C2 domains, FerA domains, and membrane anchoring through their single C-terminal transmembrane domain, and are belie...

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Detalles Bibliográficos
Autores principales: Leclère, Jean-Christophe, Dulon, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394277/
https://www.ncbi.nlm.nih.gov/pubmed/37538852
http://dx.doi.org/10.3389/fncel.2023.1197611