Apo state pore opening as functional basis of increased EAAT anion channel activity in episodic ataxia 6

SLC1A2 and SLC1A3 encode the glial glutamate transporters EAAT2 and EAAT1, which are not only the predominant glutamate uptake carriers in our brain, but also function as anion channels. Two homologous mutations, which predict substitutions of prolines in the center of the fifth transmembrane helix...

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Detalles Bibliográficos
Autores principales: Suslova, Mariia, Kortzak, Daniel, Machtens, Jan-Philipp, Kovermann, Peter, Fahlke, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394623/
https://www.ncbi.nlm.nih.gov/pubmed/37538371
http://dx.doi.org/10.3389/fphys.2023.1147216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394623/
https://www.ncbi.nlm.nih.gov/pubmed/37538371
http://dx.doi.org/10.3389/fphys.2023.1147216

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