A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across cancer types and tumorigenesis is currently unknow...

Descripción completa

Detalles Bibliográficos
Autores principales: Javaid, Hira, Barberis, Alessandro, Chervova, Olga, Nassiri, Isar, Voloshin, Vitaly, Sato, Yusuke, Ogawa, Seishi, Fairfax, Benjamin, Buffa, Francesca, Humphrey, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394884/
https://www.ncbi.nlm.nih.gov/pubmed/37528416
http://dx.doi.org/10.1186/s12885-023-11162-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394884/
https://www.ncbi.nlm.nih.gov/pubmed/37528416
http://dx.doi.org/10.1186/s12885-023-11162-0

Ejemplares similares