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A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across cancer types and tumorigenesis is currently unknow...

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Detalles Bibliográficos
Autores principales:	Javaid, Hira, Barberis, Alessandro, Chervova, Olga, Nassiri, Isar, Voloshin, Vitaly, Sato, Yusuke, Ogawa, Seishi, Fairfax, Benjamin, Buffa, Francesca, Humphrey, Timothy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394884/ https://www.ncbi.nlm.nih.gov/pubmed/37528416 http://dx.doi.org/10.1186/s12885-023-11162-0

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