The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice

Duloxetine (DLX) is widely used to treat major depressive disorder. Little is known about the mechanistic basis for DLX-related adverse effects (e.g., liver injury). Human CYP1A2 and CYP2D6 mainly contributes to DLX metabolism, which was proposed to be involved in its adverse effects. Here, we inves...

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Detalles Bibliográficos
Autores principales: Qin, Xuan, Xie, Cen, Hakenjos, John M., MacKenzie, Kevin R., Boyd, Shelton R., Barzi, Mercedes, Bissig, Karl-Dimiter, Young, Damian W., Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395004/
https://www.ncbi.nlm.nih.gov/pubmed/36513193
http://dx.doi.org/10.1016/j.ejps.2022.106358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395004/
https://www.ncbi.nlm.nih.gov/pubmed/36513193
http://dx.doi.org/10.1016/j.ejps.2022.106358

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