Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies

This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2. The new compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 cancer cell lines. Among these compounds, 15a showed the highest cytotoxicity against HepG2, with an IC(50) value of 0.76 μ...

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Detalles Bibliográficos
Autores principales: Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Elhendawy, Mostafa A., Godfrey, Murrell, Metwaly, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395314/
https://www.ncbi.nlm.nih.gov/pubmed/37538515
http://dx.doi.org/10.1039/d3ra04007k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395314/
https://www.ncbi.nlm.nih.gov/pubmed/37538515
http://dx.doi.org/10.1039/d3ra04007k

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