Cargando…

Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation

Certain arylsulfonamides (ArSulf) induce an interaction between the E3 ligase substrate adaptor DCAF15 and the critical splicing factor RBM39, ultimately causing its degradation. However, degradation of a splicing factor introduces complex pleiotropic effects that are difficult to untangle, since, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Coomar, Seemon, Mota, Pedro, Penson, Alexander, Schwaller, Jürg, Abdel-Wahab, Omar, Gillingham, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395616/
http://dx.doi.org/10.1158/1541-7786.MCR-22-0541