Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Phosphoinositide-dependent kinase-1 (PDK1) is a master kinase of the protein A, G, and C (AGC) family kinases that play important roles in regulating cancer cell proliferation, survival, and metabolism. Besides phosphorylating/activating AKT at the cell membrane in a PI3K-dependent manner, PDK1 also...

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Detalles Bibliográficos
Autores principales: Han, Dong, Wang, Wei, Jeon, Julie Heejin, Shen, Tao, Huang, Xiangsheng, Yi, Ping, Dong, Bingning, Yang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395914/
https://www.ncbi.nlm.nih.gov/pubmed/37531320
http://dx.doi.org/10.1371/journal.pbio.3002227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395914/
https://www.ncbi.nlm.nih.gov/pubmed/37531320
http://dx.doi.org/10.1371/journal.pbio.3002227

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