Cargando…

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Phosphoinositide-dependent kinase-1 (PDK1) is a master kinase of the protein A, G, and C (AGC) family kinases that play important roles in regulating cancer cell proliferation, survival, and metabolism. Besides phosphorylating/activating AKT at the cell membrane in a PI3K-dependent manner, PDK1 also...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Dong, Wang, Wei, Jeon, Julie Heejin, Shen, Tao, Huang, Xiangsheng, Yi, Ping, Dong, Bingning, Yang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395914/ https://www.ncbi.nlm.nih.gov/pubmed/37531320 http://dx.doi.org/10.1371/journal.pbio.3002227

Ejemplares similares

MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade
por: Cai, Qinbo, et al.
Publicado: (2021)

MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade
por: Wang, Wei, et al.
Publicado: (2022)

Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1–AKT pathway
por: Huang, Han-Ming, et al.
Publicado: (2022)

Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways
por: Schmitt, Danielle L., et al.
Publicado: (2018)

PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability
por: Kang, Jung-Ah, et al.
Publicado: (2017)

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
por: Lin, H-J, et al.
Publicado: (2005)

Retraction Note to: Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1–AKT pathway
por: Huang, Han-Ming, et al.
Publicado: (2022)

Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS
por: Zheng, Bo, et al.
Publicado: (2021)

Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer
por: Lucero-Acuña, Armando, et al.
Publicado: (2014)

Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease
por: Yang, Shaobin, et al.
Publicado: (2022)

A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer
por: Liu, Rangru, et al.
Publicado: (2023)

S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
por: Jiang, Qiwei, et al.
Publicado: (2022)

MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway
por: Yang, Shu, et al.
Publicado: (2021)

Hypoxia induces tumor cell growth and angiogenesis in non-small cell lung carcinoma via the Akt-PDK1-HIF1α-YKL-40 pathway
por: Miao, Yushan, et al.
Publicado: (2020)

lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway
por: Pan, Weidong, et al.
Publicado: (2019)

Complex Regulation of PKCβ2 and PDK-1/AKT by ROCK2 in Diabetic Heart
por: Lin, Guorong, et al.
Publicado: (2014)

Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway
por: Kim, Hyebeen, et al.
Publicado: (2020)

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions
por: Jiang, Qiwei, et al.
Publicado: (2021)

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma
por: Lu, Juan, et al.
Publicado: (2018)

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
por: Deng, Q, et al.
Publicado: (2013)

Naomaitai Ameliorated Brain Damage in Rats with Vascular Dementia by PI3K/PDK1/AKT Signaling Pathway
por: Huang, Kui, et al.
Publicado: (2019)

PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway
por: Pai, Shin, et al.
Publicado: (2021)

Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
por: Chen, Jia, et al.
Publicado: (2021)

SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling
por: Bao, Fan, et al.
Publicado: (2023)

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway
por: Thapa, Dharendra, et al.
Publicado: (2018)

Resveratrol Regulates Glucose and Lipid Metabolism in Diabetic Rats by Inhibition of PDK1/AKT Phosphorylation and HIF-1α Expression
por: Li, Siyun, et al.
Publicado: (2023)

A COP1-GATA2 axis suppresses AR signaling and prostate cancer
por: Shen, Tao, et al.
Publicado: (2022)

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma
por: Bamodu, Oluwaseun Adebayo, et al.
Publicado: (2020)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
por: Han, Fei, et al.
Publicado: (2017)

The Landscape of PDK1 in Breast Cancer
por: Wang, Na, et al.
Publicado: (2022)

PDK1 regulates the survival of the developing cortical interneurons
por: Wei, Yongjie, et al.
Publicado: (2020)

PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound
por: Cen, L, et al.
Publicado: (2007)

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
por: Wang, Xiao Qi, et al.
Publicado: (2017)

TCRP1 promotes NIH/3T3 cell transformation by over-activating PDK1 and AKT1
por: Wang, C, et al.
Publicado: (2017)

PDK2 promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of Sox6 and activation of JNK/MAPK/ERK pathway
por: Wang, H., et al.
Publicado: (2017)

Inhibitory Effects of Hwangryunhaedok-Tang in 3T3-L1 Adipogenesis by Regulation of Raf/MEK1/ERK1/2 Pathway and PDK1/Akt Phosphorylation
por: Kwak, Dong Hoon, et al.
Publicado: (2013)

Combination of NOS- and PDK-Inhibitory Activity: Possible Way to Enhance Antitumor Effects
por: Filimonova, Marina, et al.
Publicado: (2022)

ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
por: Kim, Min-Young, et al.
Publicado: (2015)

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
por: Castel, Pau, et al.
Publicado: (2016)

Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma
por: Velpula, Kiran K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tnq8h2suhn3pogdhn6mn2m508n