Cargando…

Dynamics of TERT regulation via alternative splicing in stem cells and cancer cells

Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jeongjin J., Sayed, Mohammed E., Ahn, Alexander, Slusher, Aaron L., Ying, Jeffrey Y., Ludlow, Andrew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395990/ https://www.ncbi.nlm.nih.gov/pubmed/37531400 http://dx.doi.org/10.1371/journal.pone.0289327

Ejemplares similares

The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
por: Slusher, Aaron L., et al.
Publicado: (2020)

Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer
por: Ludlow, Andrew T., et al.
Publicado: (2019)

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
por: Ludlow, Andrew T., et al.
Publicado: (2018)

MDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells
por: Dong, Wen, et al.
Publicado: (2016)

Alternative Splicing in Self-Renewal of Embryonic Stem Cells
por: Cheong, Clara Y., et al.
Publicado: (2011)

Alternative splicing in mesenchymal stem cell differentiation
por: Park, Jung Woo, et al.
Publicado: (2020)

Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
por: Khosravi- Maharlooei, Mohsen, et al.
Publicado: (2015)

Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors
por: Salomonis, Nathan, et al.
Publicado: (2009)

NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells
por: Sayed, Mohammed E., et al.
Publicado: (2018)

Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity
por: Liu, Xuewen, et al.
Publicado: (2017)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors
por: Yeo, Gene W, et al.
Publicado: (2007)

Alternative splicing links histone modifications to stem cell fate decision
por: Xu, Yungang, et al.
Publicado: (2018)

Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation
por: Slusher, Aaron L., et al.
Publicado: (2019)

Alternative RNA splicing in stem cells and cancer stem cells: Importance of transcript-based expression analysis
por: Ebrahimie, Esmaeil, et al.
Publicado: (2021)

Exploration of Alternative Splicing Events in Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells
por: Jeong, Ji-Eun, et al.
Publicado: (2021)

Regrowing axons with alternative splicing
por: Kramer, Nicholas J, et al.
Publicado: (2016)

Cell-to-cell variability of alternative RNA splicing
por: Waks, Zeev, et al.
Publicado: (2011)

Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma
por: Xiao, Lixing, et al.
Publicado: (2021)

Significance of alternative splicing in cancer cells
por: Qi, Fei, et al.
Publicado: (2020)

Alternative Splicing in Cancer and Immune Cells
por: Bernard, Antoine, et al.
Publicado: (2022)

Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation
por: Wang, Fang, et al.
Publicado: (2022)

Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo
por: Amor, Souheila, et al.
Publicado: (2010)

Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells
por: Behjati, Mohaddeseh, et al.
Publicado: (2017)

Determining the impact of alternative splicing events on transcriptome dynamics
por: Wilhelm, Emmanuelle, et al.
Publicado: (2008)

Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells
por: Koh, Winston, et al.
Publicado: (2016)

MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing
por: Zhai, Rong, et al.
Publicado: (2023)

Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing
por: Sakai, Akihiro, et al.
Publicado: (2020)

Hypoxia-Induced Alternative Splicing in Endothelial Cells
por: Weigand, Julia E., et al.
Publicado: (2012)

Regulation of alternative splicing at the single‐cell level
por: Faigenbloom, Lior, et al.
Publicado: (2015)

Sec16 alternative splicing dynamically controls COPII transport efficiency
por: Wilhelmi, Ilka, et al.
Publicado: (2016)

Alternative Splice in Alternative Lice
por: Tovar-Corona, Jaime M., et al.
Publicado: (2015)

Cell-type-resolved alternative splicing patterns in mouse liver
por: Wu, Peng, et al.
Publicado: (2018)

Development of alternative splicing signature in lung squamous cell carcinoma
por: Yan, Jia-qing, et al.
Publicado: (2021)

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
por: Xu, Yilin, et al.
Publicado: (2014)

Splicing and alternative splicing in rice and humans
por: E, Zhiguo, et al.
Publicado: (2013)

Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation
por: Yang, Zheqiong, et al.
Publicado: (2007)

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells
por: Jin, Lin, et al.
Publicado: (2020)

UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells
por: Zhou, Shumin, et al.
Publicado: (2022)

Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegans
por: Barberan-Soler, Sergio, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2ldqudrv67qrljgv9o205ohonq