Exposure to unmethylated CpG oligonucleotides disrupts blood pressure circadian rhythms and placental clock gene network in pregnant rats

Bacterial infections and impaired circulating mitochondrial DNA dynamics are associated with adverse pregnancy outcomes. Unmethylated cytosine-guanine dinucleotide (CpG) motifs are common in bacterial and mitochondrial DNA and act as potent immunostimulators. We tested the hypothesis that exposure t...

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Detalles Bibliográficos
Autores principales: Bradshaw, Jessica L., Cushen, Spencer C., Ricci, Contessa A., Tucker, Selina M., Gardner, Jennifer J., Little, Joel T., Osikoya, Oluwatobiloba, Goulopoulou, Styliani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396276/
https://www.ncbi.nlm.nih.gov/pubmed/37352412
http://dx.doi.org/10.1152/ajpheart.00154.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396276/
https://www.ncbi.nlm.nih.gov/pubmed/37352412
http://dx.doi.org/10.1152/ajpheart.00154.2023

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