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Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I
Respiratory complex I, a key enzyme in mammalian metabolism, captures the energy released by reduction of ubiquinone by NADH to drive protons across the inner mitochondrial membrane, generating the proton-motive force for ATP synthesis. Despite remarkable advances in structural knowledge of this com...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396290/ https://www.ncbi.nlm.nih.gov/pubmed/37531432 http://dx.doi.org/10.1126/sciadv.adi1359 |