Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

OBJECTIVES: How the local inflammatory environment regulates epigenetic changes in the context of inflammatory arthritis remains unclear. Here we assessed the transcriptional and active enhancer profile of monocytes derived from the inflamed joints of JIA patients, a model well-suited for studying i...

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Detalles Bibliográficos
Autores principales: Peeters, Janneke G C, Boltjes, Arjan, Scholman, Rianne C, Vervoort, Stephin J, Coffer, Paul J, Mokry, Michal, Vastert, Sebastiaan J, van Wijk, Femke, van Loosdregt, Jorg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396381/
https://www.ncbi.nlm.nih.gov/pubmed/36625523
http://dx.doi.org/10.1093/rheumatology/kead001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396381/
https://www.ncbi.nlm.nih.gov/pubmed/36625523
http://dx.doi.org/10.1093/rheumatology/kead001

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