Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography

Pyridoxal 5’-phosphate (PLP)-dependent enzymes utilize a vitamin B(6)-derived cofactor to perform a myriad of chemical transformations on amino acids and other small molecules. Some PLP-dependent enzymes, such as serine hydroxymethyltransferase (SHMT), are promising drug targets for the design of sm...

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Detalles Bibliográficos
Autores principales: Drago, Victoria N., Campos, Claudia, Hooper, Mattea, Collins, Aliyah, Gerlits, Oksana, Weiss, Kevin L., Blakeley, Matthew P., Phillips, Robert S., Kovalevsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397204/
https://www.ncbi.nlm.nih.gov/pubmed/37532884
http://dx.doi.org/10.1038/s42004-023-00964-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397204/
https://www.ncbi.nlm.nih.gov/pubmed/37532884
http://dx.doi.org/10.1038/s42004-023-00964-9

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