Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy

In this study we performed a step-wise optimization of biologically active IL-2 for delivery using E. coli Nissle 1917. Engineering of the strain was coupled with an in vitro cell assay to measure the biological activity of microbially produced IL-2 (mi-IL2). Next, we assessed the immune modulatory...

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Detalles Bibliográficos
Autores principales: Tumas, Sarunas, Meldgaard, Trine Sundebo, Vaaben, Troels Holger, Suarez Hernandez, Sara, Rasmussen, Annemette Tengstedt, Vazquez-Uribe, Ruben, Hadrup, Sine Reker, Sommer, Morten O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397246/
https://www.ncbi.nlm.nih.gov/pubmed/37532747
http://dx.doi.org/10.1038/s41598-023-39365-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397246/
https://www.ncbi.nlm.nih.gov/pubmed/37532747
http://dx.doi.org/10.1038/s41598-023-39365-2

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