Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin

The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological research in developing synthetic inhibitors of TRPV6, natural compounds acting at this channel have been largely neglected. On the other hand, pharmac...

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Detalles Bibliográficos
Autores principales: Neuberger, Arthur, Trofimov, Yury A., Yelshanskaya, Maria V., Khau, Jeffrey, Nadezhdin, Kirill D., Khosrof, Lena S., Krylov, Nikolay A., Efremov, Roman G., Sobolevsky, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397291/
https://www.ncbi.nlm.nih.gov/pubmed/37532722
http://dx.doi.org/10.1038/s41467-023-40362-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397291/
https://www.ncbi.nlm.nih.gov/pubmed/37532722
http://dx.doi.org/10.1038/s41467-023-40362-2

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