A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses

Lack of sufficient cytotoxic T lymphocytes (CD8(+) T cells) infiltration and dysfunctional state of CD8(+) T cells are considered enormous obstacles to antitumor immunity. Herein, we construct a synergistic nanoplatform to promote CD8(+) T cell infiltration in tumors while restoring T cell function...

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Detalles Bibliográficos
Autores principales: Huang, Ying, Qin, Geng, Cui, TingTing, Zhao, Chuanqi, Ren, Jinsong, Qu, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397352/
https://www.ncbi.nlm.nih.gov/pubmed/37532731
http://dx.doi.org/10.1038/s41467-023-40345-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397352/
https://www.ncbi.nlm.nih.gov/pubmed/37532731
http://dx.doi.org/10.1038/s41467-023-40345-3

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