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A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses
Lack of sufficient cytotoxic T lymphocytes (CD8(+) T cells) infiltration and dysfunctional state of CD8(+) T cells are considered enormous obstacles to antitumor immunity. Herein, we construct a synergistic nanoplatform to promote CD8(+) T cell infiltration in tumors while restoring T cell function...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397352/ https://www.ncbi.nlm.nih.gov/pubmed/37532731 http://dx.doi.org/10.1038/s41467-023-40345-3 |