Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system

β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-Tr...

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Detalles Bibliográficos
Autores principales: LIU, XINTONG, SANADA, EMIKO, LI, JIANG, LI, XIAOMENG, OSADA, HIROYUKI, WATANABE, NOBUMOTO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398414/
https://www.ncbi.nlm.nih.gov/pubmed/37547765
http://dx.doi.org/10.32604/or.2023.030240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398414/
https://www.ncbi.nlm.nih.gov/pubmed/37547765
http://dx.doi.org/10.32604/or.2023.030240

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