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Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system

β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-Tr...

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Detalles Bibliográficos
Autores principales:	LIU, XINTONG, SANADA, EMIKO, LI, JIANG, LI, XIAOMENG, OSADA, HIROYUKI, WATANABE, NOBUMOTO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Tech Science Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398414/ https://www.ncbi.nlm.nih.gov/pubmed/37547765 http://dx.doi.org/10.32604/or.2023.030240

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