PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

The protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed‐forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin activation, and ubiquitylation of mitochondrial outer membrane proteins to support the recruitment of mitophagy receptors....

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Detalles Bibliográficos
Autores principales: Kraus, Felix, Goodall, Ellen A, Smith, Ian R, Jiang, Yizhi, Paoli, Julia C, Adolf, Frank, Zhang, Jiuchun, Paulo, Joao A, Schulman, Brenda A, Harper, J Wade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398645/
https://www.ncbi.nlm.nih.gov/pubmed/37334901
http://dx.doi.org/10.15252/embr.202256399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398645/
https://www.ncbi.nlm.nih.gov/pubmed/37334901
http://dx.doi.org/10.15252/embr.202256399

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