An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3–RIF1 interaction critical for shieldin activity

53BP1 is a chromatin‐binding protein that promotes DNA double‐strand break repair through the recruitment of downstream effectors including RIF1, shieldin, and CST. The structural basis of the protein–protein interactions within the 53BP1‐RIF1‐shieldin‐CST pathway that are essential for its DNA repa...

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Detalles Bibliográficos
Autores principales: Sifri, Chérine, Hoeg, Lisa, Durocher, Daniel, Setiaputra, Dheva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398656/
https://www.ncbi.nlm.nih.gov/pubmed/37306046
http://dx.doi.org/10.15252/embr.202356834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398656/
https://www.ncbi.nlm.nih.gov/pubmed/37306046
http://dx.doi.org/10.15252/embr.202356834

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