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An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3–RIF1 interaction critical for shieldin activity
53BP1 is a chromatin‐binding protein that promotes DNA double‐strand break repair through the recruitment of downstream effectors including RIF1, shieldin, and CST. The structural basis of the protein–protein interactions within the 53BP1‐RIF1‐shieldin‐CST pathway that are essential for its DNA repa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398656/ https://www.ncbi.nlm.nih.gov/pubmed/37306046 http://dx.doi.org/10.15252/embr.202356834 |