Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

[Image: see text] The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping machinery could be one of the therapeutic concepts based on a unique mechanism of action. Viral RNA cap synthesis involves...

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Detalles Bibliográficos
Autores principales: Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398685/
https://www.ncbi.nlm.nih.gov/pubmed/37546609
http://dx.doi.org/10.1021/acsomega.3c02815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398685/
https://www.ncbi.nlm.nih.gov/pubmed/37546609
http://dx.doi.org/10.1021/acsomega.3c02815

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