Cargando…

Preferability of Molnupiravir, an Anti-COVID-19 Drug, toward Purine Nucleosides: A Quantum Mechanical Study

[Image: see text] Structural aspects of molnupiravir complexed with the RNA of the SARS-CoV-2 virus have been recently resolved inside the RNA-dependent RNA polymerase (RdRp), demonstrating the interactions of molnupiravir with purine nucleosides. However, the preference of molnupiravir to interact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibrahim, Mahmoud A. A., Shehata, Mohammed N. I., Moussa, Nayra A. M., Hemia, Randa R. A., Abd Elhafez, Heba S. M., Abd El-Rahman, Mohamed K., Sayed, Shaban R. M., Sidhom, Peter A., Dabbish, Eslam, Shoeib, Tamer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398865/ https://www.ncbi.nlm.nih.gov/pubmed/37546583 http://dx.doi.org/10.1021/acsomega.3c03215

Ejemplares similares

Elucidating the adsorption of 2-Mercaptopyridine drug on the aluminum phosphide (Al(12)P(12)) nanocage: A DFT study
por: Rady, Al-shimaa S.M., et al.
Publicado: (2023)

Adsorption Features of Tetrahalomethanes (CX(4); X = F, Cl, and Br) on β(12) Borophene and Pristine Graphene Nanosheets: A Comparative DFT Study
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

Adsorption of Favipiravir on pristine graphene nanosheets as a drug delivery system: a DFT study
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

On the Use of Graphene Nanosheets for Drug Delivery: A Case Study of Cisplatin and Some of Its Analogs
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

Density functional theory study of the corrosion inhibition performance of 6-mercaptopurine and 6-thioguanine expired drugs toward the aluminium (111) surface
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

A green compliant hand-held selective electrode device for monitoring active pharmaceuticals and the kinetics of their degradation
por: Badr ElDin, Norhan, et al.
Publicado: (2023)

In-Silico Mining of the Toxins Database (T3DB) towards Hunting Prospective Candidates as ABCB1 Inhibitors: Integrated Molecular Docking and Lipid Bilayer-Enhanced Molecular Dynamics Study
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

Anti-Cancer Peptides: Status and Future Prospects
por: Ghaly, Gehane, et al.
Publicado: (2023)

Effects of Lewis Basicity and Acidity on σ-Hole Interactions in Carbon-Bearing Complexes: A Comparative Ab Initio Study
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2022)

Sigma-Hole and Lone-Pair-Hole Site-Based Interactions of Seesaw Tetravalent Chalcogen-Bearing Molecules with Lewis Bases
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2023)

Diverse models for anti-HIV activity of purine nucleoside analogs
por: Khatri, Naveen, et al.
Publicado: (2015)

Purine nucleosides: endogenous neuroprotectants in hypoxic brain
por: Thauerer, Bettina, et al.
Publicado: (2012)

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007
por: Liu, Gaofei, et al.
Publicado: (2019)

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations
por: Yehia, Heba, et al.
Publicado: (2020)

Identification of a transcription factor, PunR, that regulates the purine and purine nucleoside transporter punC in E. coli
por: Rodionova, Irina A., et al.
Publicado: (2021)

Purine nucleoside phosphorylase is associated with centrioles and basal bodies
Publicado: (1981)

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
por: Chaikuad, Apirat, et al.
Publicado: (2009)

Thermus thermophilus Strains Active in Purine Nucleoside Synthesis
por: Almendros, Marcos, et al.
Publicado: (2009)

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides
por: Beamer, Edward, et al.
Publicado: (2021)

Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase
por: Donaldson, Teraya M., et al.
Publicado: (2014)

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients
por: Alangari, Abdullah, et al.
Publicado: (2009)

Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives
por: Ren, Hang, et al.
Publicado: (2019)

The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a ‘spanner in the works’
por: Given, Fiona M., et al.
Publicado: (2022)

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval
por: Ashour, Nada A, et al.
Publicado: (2022)

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
por: Hasaneen, Noha, et al.
Publicado: (2019)

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions
por: Birder, Lori A., et al.
Publicado: (2020)

Effects of the intravenous administration of purine nucleosides guanosine or inosine against hemorrhagic shock in pigs
por: Schmidt, A, et al.
Publicado: (2012)

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response
por: Dhanwani, Rekha, et al.
Publicado: (2020)

Computational Analysis of Molnupiravir
por: Sharov, Artem V., et al.
Publicado: (2022)

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides
por: Ren, Hang, et al.
Publicado: (2015)

Anti‐flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues
por: McGuigan, Christopher, et al.
Publicado: (2016)

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation
por: Liang, Yong, et al.
Publicado: (2015)

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides
por: Rao, Jagadeeshwar R., et al.
Publicado: (2007)

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
por: Kropotov, Andrey, et al.
Publicado: (2022)

Metabolites of Purine Nucleoside Phosphorylase (NP) in Serum Have the Potential to Delineate Pancreatic Adenocarcinoma
por: Vareed, Shaiju K., et al.
Publicado: (2011)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2022)

GDF‐15 is associated with atherosclerosis in adults with transfusion‐dependent beta‐thalassemia
por: Efat, Alaa, et al.
Publicado: (2022)

Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters
por: Aldfer, Mustafa M., et al.
Publicado: (2022)

8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity
por: Jackson, Edwin K., et al.
Publicado: (2022)

Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food
por: Mahor, Durga, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1q83k3jh4fcsdjufg0n7qe87c9