Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly

Polo-like kinase 4 (Plk4) is the master-regulator of centriole assembly, and cell cycle–dependent regulation of its activity maintains proper centrosome number. During most of the cell cycle, Plk4 levels are nearly undetectable due to its ability to autophosphorylate and trigger its own ubiquitin-me...

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Detalles Bibliográficos
Autores principales: Ryniawec, John M., Buster, Daniel W., Slevin, Lauren K., Boese, Cody J., Amoiroglou, Anastasia, Dean, Spencer M., Slep, Kevin C., Rogers, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398880/
https://www.ncbi.nlm.nih.gov/pubmed/37163316
http://dx.doi.org/10.1091/mbc.E22-12-0572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398880/
https://www.ncbi.nlm.nih.gov/pubmed/37163316
http://dx.doi.org/10.1091/mbc.E22-12-0572

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