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Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly
Polo-like kinase 4 (Plk4) is the master-regulator of centriole assembly, and cell cycle–dependent regulation of its activity maintains proper centrosome number. During most of the cell cycle, Plk4 levels are nearly undetectable due to its ability to autophosphorylate and trigger its own ubiquitin-me...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398880/ https://www.ncbi.nlm.nih.gov/pubmed/37163316 http://dx.doi.org/10.1091/mbc.E22-12-0572 |